Hajos.E2.80.93Parrish.E2.80.93Eder.E2.80.93Sauer.E2.80.93Wiechert reaction Enamine

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this example of 6-enolendo aldolization.


a prominent example of proline catalysis addition of acetone or hydroxyacetone diverse set of aldehydes catalyzed 20-30% proline catalyst loading high (>99%) enantioselectivity yielding diol products. chemistry studied barbas group @ scripps research institute, , later refined list , notz used aforementioned reaction produce diol products follows:










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