Expression and function Interleukin-8 receptor

a neutrophil in among population of red blood cells. neutrophils main target cells il-8, , contain large number of il-8 receptors on cell surfaces. binding causes neutrophil migrate site of infection.

both il-8ra , il-8rb expressed in neutrophils, monocytes, macrophages, basophils, t-lymphocytes, , endothelial cells. il-8rb expressed additionally in neurons of central nervous system. il-8ra highly specific interleukin-8 , responds when particular ligand bound receptor site, exhibiting specific binding behavior. il-8rb binds il-8 same affinity il-8ra, binds neutrophil-activating protein 2 (nap-2) , other small receptor molecules of cxc chemokine family lower affinity il-8 binding, exhibiting shared binding behavior. chemokines class of small molecules induce recruitment of leukocytes , stimulate pro-inflammatory responses; responsiveness of il-8r chemokines suggests heavily involved in recruitment of white blood cells inflammatory , immunological response purposes.

the binding of il-8 receptor induces following 3 main responses in neutrophils, of assist neutrophil in developing molecular mechanisms target , kill pathogens: shape , conformational change of neutrophil (which allows transendothelial migration of cell), degranulation (causing release of enzymes within cell), , dissociation of heterotrimeric g-proteins (a typical effect of ligands binding 7tm g-protein coupled receptors), thereby activating them. activation of g-proteins leads signal transduction , phosphorylation cascades, ultimate affect of changing gene expression of neutrophil allow recruitment of other white blood cells local area.