Pharmacodynamics Dosulepin

-



dosulepin transporter blocker of serotonin transporter (sert) , norepinephrine transporter (net), thereby acting snri. antagonist of histamine h1 receptor, α1-adrenergic receptor, serotonin 5-ht2 receptors, , muscarinic acetylcholine receptors (mach), blocker of voltage-gated sodium channels (vgscs). antidepressant effects of dosulepin thought due inhibition of reuptake of norepinephrine , possibly of serotonin.


dosulepin has 3 metabolites, northiaden (desmethyldosulepin), dosulepin sulfoxide, , northiaden sulfoxide, have longer terminal half-lives of dosulepin itself. however, whereas northiaden has potent activity dosulepin, 2 sulfoxide metabolites have dramatically reduced activity. have been described inactive, , considered unlikely contribute either therapeutic effects or side effects of dosulepin. relative dosulepin, northiaden has reduced activity serotonin reuptake inhibitor, antihistamine, , anticholinergic , greater potency norepinephrine reuptake inhibitor, other secondary amine tcas. unlike sulfoxide metabolites, northiaden thought play important role in effects of dosulepin.


although heal & cheetham (1992) reported relatively high ki values of 12 , 15 nm dosulepin , northiaden @ rat α2-adrenergic receptor , suggested antagonism of receptor involved in antidepressant effects of dosulepin, richelson & nelson (1984) found low kd of 2,400 nm dosulepin @ receptor using human brain tissue. suggests in fact has low potency action, other tcas.








Comments

Post a Comment

Popular posts from this blog

Gigantomastia Breast hypertrophy

-
the first recorded case of gigantomastia, diagnosed in 23- or 24-year-old woman, circa 1670. in 1670, physician durston drew illustration of first recorded case of non-gravid gigantomastia; woman died of condition. a painting lam qua of lu-shi, age 42, on april 17, 1848, prior breast reduction surgery. one , extreme case study of gigantomastia dates 1670. patient died 4 months after onset of enlargement. 1 breast removed after woman s death weighed 29 kg (64 lb). on april 17, 1848, 42-year-old woman named lu-shi treated hypertrophy in chinese hospital. treated missionary physician. on december 24, 1849, left breast, measuring 67 cm (26.5 in) in circumference, , weighing 2.7 kg (6 lb), removed in procedure lasting 3 , half minutes. right breast removed 1 month later. measured 61 cm (24 in) in circumference , weighed 2.5 kg (5.5 lb). in 2005, woman reported breasts grew @ puberty nothing c cup in 1 month. when became pregnant first time, breasts increased 2 cup sizes in few days. after f
Read more

Release information Conversations with Other Women

-
1 release information 1.1 theatrical release 1.2 dvd release 1.3 critical reception release information theatrical release conversations, canosa s directorial debut, premiered @ 2005 telluride film festival. film subsequently played @ tokyo international film festival, seminci valladolid international film festival, comedy arts festival, south southwest film festival, seattle international film festival, los angeles film festival, rio de janeiro international film festival, hamburg film festival, são paulo international film festival, , muestra internacional de cine. the film s international theatrical premiere on june 7, 2006 in france. released distributor mk2 diffusion under title conversations avec une femme, film played theatrically 5 months both box office success , critical acclaim. released on august 11, 2006 in united states fabrication films, film played in fourteen cities, garnering modest theatrical box office , critical acclaim. dvd release the original split-screen region
Read more

Operation Unified Task Force

-
a marine 8x8 lav-25 (light armored vehicle) 3rd light armor infantry battalion (left), , italian soldiers in 4x4 fiat-oto melara type 6614 armored personnel carrier (right), guard intersection on green line in mogadishu. the operation began on 6 december 1992, when u.s. navy seals , special boat crewmen naval special warfare task unit tripoli began conducting reconnaissance operations in vicinity of airport , harbor. these operations lasted 3 days. in hours of 8 december 1992 elements of army s 4th psychological operations group (airborne) attached 15th marine expeditionary unit (meu) conducted leaflet drops on capital city of mogadishu. on 9 december, meu performed unopposed amphibious assault city of mogadishu uss tripoli (lph-10), uss juneau (lpd-10) , uss rushmore (lsd-47). the meu s ground combat element, 2nd battalion 9th marines (2/9), performed simultaneous raids on port of mogadishu , mogadishu international airport, establishing foothold additional incoming troops. echo , g
Read more